{"id":228952,"date":"2022-06-15T15:36:16","date_gmt":"2022-06-15T13:36:16","guid":{"rendered":"https:\/\/mypr.co.za\/?p=117161"},"modified":"2022-06-15T15:36:16","modified_gmt":"2022-06-15T13:36:16","slug":"cipla-and-dndi-launch-child-friendly-4-in-1-antiretroviral-treatment-for-young-children-living-with-hiv-in-south-africa","status":"publish","type":"post","link":"https:\/\/www.myza.co.za\/press\/cipla-and-dndi-launch-child-friendly-4-in-1-antiretroviral-treatment-for-young-children-living-with-hiv-in-south-africa\/","title":{"rendered":"Cipla and DNDi launch child-friendly 4-in-1 antiretroviral treatment for young children living with HIV in South Africa"},"content":{"rendered":"<aside class=\"scaip scaip-1 \">\n<aside id=\"republication_tracker_tool-2\" class=\"republication_tracker_tool clearfix\">\n<h5 class=\"adtitle\">Republish for Free<\/h5>\n<div class=\"license\">\n<p><button name=\"Republish This Story\" id=\"cc-btn\" class=\"republication-tracker-tool-button\">Republish This Story<\/button><\/p>\n<p><a class=\"license\" rel=\"noreferrer license noopener\" target=\"_blank\" href=\"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/\"><img decoding=\"async\" alt=\"Creative Commons License\" class=\"lazyload\" src=\"http:\/\/www.myza.co.za\/press\/wp-content\/uploads\/2022\/06\/cipla-and-dndi-launch-child-friendly-4-in-1-antiretroviral-treatment-for-young-children-living-with-hiv-in-south-africa.png\"><\/a><\/p>\n<p><img decoding=\"async\" alt=\"Creative Commons License\" src=\"http:\/\/www.myza.co.za\/press\/wp-content\/uploads\/2022\/06\/cipla-and-dndi-launch-child-friendly-4-in-1-antiretroviral-treatment-for-young-children-living-with-hiv-in-south-africa.png\"><\/div>\n<div class=\"message\">\n<p>Republish our articles for free, online or in print, under a Creative Commons license.<\/p>\n<\/div>\n<\/aside>\n<\/aside>\n<p><a href=\"https:\/\/mypr.co.za\/?attachment_id=117162\"><img loading=\"lazy\" decoding=\"async\" alt width=\"300\" height=\"200\" class=\"alignleft wp-image-117162 size-thumbnail lazyload\" src=\"http:\/\/www.myza.co.za\/press\/wp-content\/uploads\/2022\/06\/cipla-and-dndi-launch-child-friendly-4-in-1-antiretroviral-treatment-for-young-children-living-with-hiv-in-south-africa.jpg\"><\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-117162 size-thumbnail\" src=\"http:\/\/www.myza.co.za\/press\/wp-content\/uploads\/2022\/06\/cipla-and-dndi-launch-child-friendly-4-in-1-antiretroviral-treatment-for-young-children-living-with-hiv-in-south-africa.jpg\" alt width=\"300\" height=\"200\">Cipla and DNDi launch child-friendly 4-in-1 antiretroviral treatment for young children living with HIV in South Africa<\/p>\n<p>CAPE TOWN- 15 June 2022 \u2013 The South African Health Products Regulatory Authority (SAHPRA) has approved a sweet-tasting, heat-stable, \u20184-in-1\u2019 fixed-dose combination of four antiretroviral (ARV) treatments composed of abacavir, lamivudine, lopinavir, and ritonavir that is specifically designed for infants and young children with HIV. This combination treatment has been developed by Cipla Limited and the not-for-profit Drugs for Neglected Diseases initiative (DNDi).<\/p>\n<p>This new formulation represents a significant improvement over protease inhibitor-containing paediatric ARV formulations that have been used in South Africa for decades. It does not require refrigeration, has a sweet taste and is easy to administer to infants and children of different weights and ages, a major improvement for both children and their caregivers over previously available formulations. The country has 238,000 children under the age of 15 living with HIV \u2013 the highest in the world [1].<\/p>\n<p>\u201cIt is highly significant that this first regulatory approval of the \u20184-in-1\u2019 formulation is from a country that has a high burden of HIV among children,\u201d said Dr Irene Mukui, Head of HIV, DNDi. \u201cSAHPRA\u2019s accelerated review is notable and encouraging for other high-burden countries, and we acknowledge this show of commitment by the South African authorities. Now, it is our hope that all the necessary steps will be taken \u2013 first in South Africa and then in other countries \u2013 to ensure the broadest possible access to this optimal formulation for young children who need it.\u201d<\/p>\n<p>The \u20184-in-1\u2019 combination contains an antiretroviral combination that is recommended by the World Health Organization (WHO) as an alternative first-line regimen for infants and young children with HIV \u2013 in the form of granule-filled capsules. Caretakers will be able to give the medicine to children by sprinkling the granules over soft food like porridge or dissolving it in water or milk.<\/p>\n<p>Commenting on the development, Umang Vohra, Managing Director and Global CEO, Cipla said: \u201cWe are guided by our strong sense of responsibility to address unmet patient needs and we are committed to bringing novel solutions to improve lives. This approval has come at an important time when so many children are suffering from HIV at such a young age. We will continue in our endeavour to enable access to life saving solutions for all.\u201d<\/p>\n<p>Until recently, the only WHO-recommended lopinavir-based treatment available for babies and very young children in South Africa consisted of a syrup that contained 40% alcohol and required refrigeration. Caregivers struggled to give this bitter-tasting formulation to young children, leading to poor adherence. Caregivers without refrigeration had a very difficult time storing the formulations \u2013 sometimes burying them in the ground to keep them cold.<\/p>\n<p>Now, there are multiple new child-friendly formulations of WHO-recommended regimens being introduced \u2013 including paediatric formulations of dolutegravir-containing regimens \u2013 representing a long-awaited and long overdue \u2018treatment revolution\u2019 for children with HIV.<\/p>\n<p>\u201cSouth Africa has made major advances in the treatment of adults living with HIV, but as in the rest of Africa, children with HIV have been left behind, in part because the treatment options we have are not child-friendly,\u201d said Professor Moherndran Archery, who represents Child and Adolescent Interests at the Southern African HIV Clinicians Society (SAHCS). \u201cAlthough 72% of South African adults are on life-saving HIV treatment, just half of children living with HIV in the country are on treatment. Along with other optimal ARV formulations being introduced in South Africa, the approval of the 4-in-1 is a step towards closing this gap and ending the neglect of children with HIV.\u201d<\/p>\n<p>Without treatment, half of children with HIV will die before turning two. Worldwide, 2.78 million children and adolescents are living with HIV \u2013 88% of them in sub-Saharan Africa \u2013 but only 54% have access to treatment, according to UNICEF.<\/p>\n<p>Paul Miller, CEO of Cipla South Africa, said: \u201cFor more than 20 years, Cipla has ensured equitable access to affordable, lifesaving ARVs, and we are pleased to be continuing this commitment by providing optimal child-friendly antiretroviral formulations, especially for infants and young children who are at highest risk of dying without access to treatment.\u201d<\/p>\n<p>The 4-in-1 was developed and registered with the financial support of Unitaid; the French Development Agency; the Swiss Agency for Development and Cooperation; M\u00e9decins Sans Fronti\u00e8res International; the UBS Optimus Foundation; the Monegasque Cooperation for Development; MSF Norway; the Spanish Agency for International Development Cooperation; and other private foundations and individuals.<\/p>\n<p><a href=\"http:\/\/mypr.co.za\/contact\/featured\/\">CLICK HERE to submit your press release to MyPR.co.za<\/a>.<\/p>\n<p> <span class=\"post-views-icon dashicons dashicons-chart-bar\"><\/span> <span class=\"post-views-label\">Press Release Views:<\/span> <span class=\"post-views-count\">51<\/span> <\/p>\n<div class=\"entry-pagination pagination\">Pages: <span class=\"post-page-numbers current\"><span class=\"screen-reader-text\">Page <\/span>1<\/span> <a href=\"https:\/\/mypr.co.za\/cipla-and-dndi-launch-child-friendly-4-in-1-antiretroviral-treatment-for-young-children-living-with-hiv-in-south-africa\/2\/\" class=\"post-page-numbers\"><span class=\"screen-reader-text\">Page <\/span>2<\/a><\/div>\n<p><a href=\"https:\/\/mypr.co.za\">Source: MyPR.co.za<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Republish for Free Republish This Story Republish our articles for free, online or in print, under a Creative Commons license. Cipla and DNDi launch child-friendly 4-in-1 antiretroviral treatment for young children living with HIV in South Africa CAPE TOWN- 15 June 2022 \u2013 The South African Health Products Regulatory Authority (SAHPRA) has approved a sweet-tasting, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":228953,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","ngg_post_thumbnail":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[3331,9021],"tags":[3257],"class_list":{"0":"post-228952","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-cape-town","8":"category-mypr","9":"tag-mypr","10":"entry"},"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/www.myza.co.za\/press\/wp-content\/uploads\/2022\/06\/cipla-and-dndi-launch-child-friendly-4-in-1-antiretroviral-treatment-for-young-children-living-with-hiv-in-south-africa.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/posts\/228952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/comments?post=228952"}],"version-history":[{"count":0,"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/posts\/228952\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/media\/228953"}],"wp:attachment":[{"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/media?parent=228952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/categories?post=228952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/tags?post=228952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}