{"id":57764,"date":"2015-11-17T14:47:37","date_gmt":"2015-11-17T12:47:37","guid":{"rendered":"http:\/\/www.myza.co.za\/2015\/11\/parts-of-southern-africa-are-within-tantalising-reach-of-eliminating-malaria-the-conversation\/"},"modified":"2015-11-17T14:47:37","modified_gmt":"2015-11-17T12:47:37","slug":"parts-of-southern-africa-are-within-tantalising-reach-of-eliminating-malaria-the-conversation","status":"publish","type":"post","link":"https:\/\/www.myza.co.za\/press\/parts-of-southern-africa-are-within-tantalising-reach-of-eliminating-malaria-the-conversation\/","title":{"rendered":"Parts of southern Africa are within tantalising reach of eliminating malaria | The Conversation"},"content":{"rendered":"<figure><img decoding=\"async\" src=\"https:\/\/62e528761d0685343e1c-f3d1b99a743ffa4142d9d7f1978d9686.ssl.cf2.rackcdn.com\/files\/100338\/width496\/image-20151030-16554-1qj7h1i.jpg\" \/><figcaption><span class=\"caption\">A young girl plays inside a mosquito net in Kibera, Nairobi. <\/span> <span class=\"attribution\"><span class=\"source\">EPA\/Stephen Morrison<\/span><\/span><\/figcaption><\/figure>\n<p><em><em>This article is part of a series The Conversation Africa is running as part of the SADC malaria week. You can read the rest of the series here.<\/em><\/em><\/p>\n<p>There has been a concerted international effort since the early 2000s to tackle malaria. This has led to dramatic reductions in the disease.<\/p>\n<p>World Health Organisation estimates show that in 2015 there were 214 million malaria cases and 438,000 deaths globally. This is a 37% decrease in the incidence rate of malaria compared to 15 years ago and a 60% reduction in deaths.<\/p>\n<p>Most of the gains have happened in Asia and \u201cfringe\u201d areas in Africa, which is at the periphery of distribution of the disease. But the challenge is that sub-Saharan Africa still shoulders 89% of existing cases and 91% of deaths from the disease.<\/p>\n<h2>How successes have been achieved<\/h2>\n<p>Africa has historically had a high transmission rate. Southern Africa has been particularly successful in reducing its case load. The Seychelles and Mauritius have completely eliminated malaria. They have had no new local transmissions in recent years \u2013 only some imported cases that were locally diagnosed and treated.<\/p>\n<p>In South Africa there was an exceptional peak of 64,622 cases in 2000. Since then case numbers have dwindled to between 6000 and 10,000 in recent years.<\/p>\n<p>This reflects reductions in several of South Africa\u2019s neighbouring countries such as Botswana, Namibia, and Swaziland \u2013 where malaria mortality rates are close to zero.<\/p>\n<p>These four countries are in the pre-elimination and elimination stages. Malaria incidence in all of them makes up less than five cases per thousand people. This means they are within sight of eliminating malaria \u2013 a tantalising target that South Africa hopes to reach by 2018.<\/p>\n<p>But that reward is proving hard to achieve despite the dedicated efforts by the national malaria control programs in each country.<\/p>\n<h2>The reasons why full elimination is so difficult<\/h2>\n<p>The standard tools used almost universally for malaria control are:<\/p>\n<ul>\n<li>\n<p>providing households with insecticide-treated bednets (ITNs);<\/p>\n<\/li>\n<li>\n<p>indoor residual spraying (IRS) of insecticides against mosquitoes that enter households; and<\/p>\n<\/li>\n<li>\n<p>dedicated efforts to detect malaria cases and treat them with effective anti-malarial drugs.<\/p>\n<\/li>\n<\/ul>\n<p>When these three tools are used in combination, they have resulted in the reversal and decline in malaria cases almost globally. But what was once an effective approach to harvest the low-hanging fruit to achieve relatively quick success have now become blunt tools.<\/p>\n<p>The interventions now lack the surgical precision to clear up what is known as \u201cresidual malaria\u201d. These are the portion of cases that pop up for reasons that are not always known and do not yield to persistent use of the traditional tools.<\/p>\n<p>A major contributing factor, especially in the case of South Africa, is the large numbers of migrants and visitors from high-transmission malaria countries further north. Although Gauteng, South Africa\u2019s economic hub, was never a problem province, it now has the highest number of cases in the country.<\/p>\n<p>The cases are through infected people entering the country and becoming ill once they have arrived, or vehicles returning from high-transmission countries with malaria-infected mosquitoes hitching a ride.<\/p>\n<p>There are other reasons too.<\/p>\n<p>Some countries do not have a policies to deal effectively with the particular life stages that infect mosquitoes. Malaria parasites have a complex life cycle involving different forms having different target organs and functions. Only one stage \u2013 the sexual gametocytes \u2013 are able to infect mosquitoes that leads to infecting other people.<\/p>\n<p>Although doctors prescribe medication that kills the numerous asexual parasites in the blood which then cures infected people of the malaria symptoms, it does not effectively inactivate the sexual gametocytes that infect mosquitoes, at least in Africa where the deadliest species of malaria parasite is most common.<\/p>\n<p>There are also chronic systemic challenges. These include a shortage of manpower, funding, lost skills that are not replaced, and a mindset still geared to the decades-long traditional approach to combat malaria.<\/p>\n<h2>New frontier<\/h2>\n<p>Entering the elimination stage is a relatively new frontier for the southern African countries.<\/p>\n<p>There are more hazy possibilities that come into play with residual malaria. This includes the unknown role of secondary vectors. Traditional malaria control tools have targeted a very limited set of mainly three mosquito species with known behaviour.<\/p>\n<p>Addressing these three species has resulted in successes. But with residual malaria we may be dealing with unknown secondary vector mosquitoes that previously played a minor role but now keep the disease ticking over.<\/p>\n<p>Also, across the world there are increasing numbers of countries where mosquito populations are building resistance to available insecticides used for spraying. What is more concerning is that malaria parasites are also developing resistance to the only, and best, available anti-malarial compound, artemisinin.<\/p>\n<p>This resistance is currently still confined to geographic pockets in southeast Asia, but precedents exist where such resistance rapidly spreads to other parts of the globe.<\/p>\n<p>Another concern is loss of political will to continue the high financial and other demands associated with effective malaria programs \u2013 and donor fatigue.<\/p>\n<p>Most of the money being poured into malaria control at global scale comes from international donors. Once again precedent has shown that in the face of diminishing returns such donors lose commitment.<\/p>\n<h2>The last lap<\/h2>\n<p>Botswana, Namibia, South Africa and Swaziland \u2013 unlike many other African countries confronted with particular economic and political challenges \u2013 are very likely to achieve zero local transmission.<\/p>\n<p>The lessons learnt in South Africa and its neighbours is of great importance. There is some urgency in cementing these successes.<\/p>\n<p>But then the real challenge will emerge: the will of national governments to continue funding a program that has achieved its goal. The moment it weakens its defences, malaria is likely to rebound extremely quickly in the face of migration and importation from high-transmission neighbouring countries that are still fighting to bring malaria under control.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" alt=\"The Conversation\" height=\"1\" src=\"https:\/\/counter.theconversation.edu.au\/content\/49848\/count.gif\" width=\"1\" \/> <\/p>\n<p><em><span>Professor Leo Braack received funding from Bill and Melinda Gates Foundation and University of Pretoria for research on malaria.<\/span><\/em><\/p>\n<p><a rel=\"nofollow\" href=\"http:\/\/theconversation.com\/parts-of-southern-africa-are-within-tantalising-reach-of-eliminating-malaria-49848\">The Conversation \u2013 Articles (AFRICA)<\/a><\/p>\n<p>Read more on <a href=\"http:\/\/theconversation.com\" target=\"_blank\">The Conversation<\/a>.<\/p>\n<p><strong>Join the fun:<\/strong> <a href=\"http:\/\/www.myza.co.za\/add-your-event\/\">Add Your event<\/a> | <a href=\"http:\/\/www.mypr.co.za\/submit\">Submit a Press Release<\/a> | <a href=\"http:\/\/www.myza.co.za\/directory\/\">Add your listing<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A young girl plays inside a mosquito net in Kibera, Nairobi. EPA\/Stephen Morrison This article is part of a series The Conversation Africa is running as part of the SADC malaria week. You can read the rest of the series here. There has been a concerted international effort since the early 2000s to tackle malaria. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","ngg_post_thumbnail":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[4584],"tags":[428,8890,9003,1766,5931,2347,7407,9002,9001],"class_list":{"0":"post-57764","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-africa-news-2","7":"tag-africa","8":"tag-conversation","9":"tag-eliminating","10":"tag-malaria","11":"tag-parts","12":"tag-reach","13":"tag-southern","14":"tag-tantalising","15":"tag-within","16":"entry"},"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/posts\/57764","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/comments?post=57764"}],"version-history":[{"count":0,"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/posts\/57764\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/media?parent=57764"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/categories?post=57764"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.myza.co.za\/press\/wp-json\/wp\/v2\/tags?post=57764"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}